David Bermudes Selected Research

VNP 20009 (VNP20009)

12/2018	Co-Expression of a Chimeric Protease Inhibitor Secreted by a Tumor-Targeted Salmonella Protects Therapeutic Proteins from Proteolytic Degradation.
12/2016	EGFR-targeted Chimeras of Pseudomonas ToxA released into the extracellular milieu by attenuated Salmonella selectively kill tumor cells.
1/2009	Tumor-targeted Salmonella typhimurium overexpressing cytosine deaminase: a novel, tumor-selective therapy.
7/2008	Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy.
1/2005	Positron emission tomography (PET) imaging of tumor-localized Salmonella expressing HSV1-TK.
1/2004	Construction of VNP20009: a novel, genetically stable antibiotic-sensitive strain of tumor-targeting Salmonella for parenteral administration in humans.
7/2002	Tumor-targeted Salmonella expressing cytosine deaminase as an anticancer agent.
3/2002	Live bacteria as anticancer agents and tumor-selective protein delivery vectors.

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David Bermudes Research Topics

Disease

13	Neoplasms (Cancer) 12/2018 - 03/2002
2	Leukemia 01/2011 - 09/2010
1	Breast Neoplasms (Breast Cancer) 12/2018
1	Septic Shock (Toxic Shock Syndrome) 01/2016
1	Carcinoma (Carcinomatosis) 07/2008
1	Melanoma (Melanoma, Malignant) 07/2008
1	Colorectal Neoplasms (Colorectal Cancer) 06/2008
1	Herpes Simplex 01/2005

Drug/Important Bio-Agent (IBA)

8	VNP 20009 (VNP20009)IBA 12/2018 - 03/2002
3	Proteins (Proteins, Gene)FDA Link 12/2018 - 03/2002
3	Cytosine DeaminaseIBA 01/2009 - 03/2002
3	ProdrugsIBA 07/2008 - 07/2002
2	Pharmaceutical PreparationsIBA 01/2011 - 09/2010
2	EnzymesIBA 07/2008 - 07/2002
2	Antineoplastic Agents (Antineoplastics)IBA 07/2002 - 03/2002
1	TrypsinIBA 12/2018
1	Protease Inhibitors (Protease Inhibitor)IBA 12/2018
1	Rhodamine 123IBA 12/2016
1	Coloring Agents (Dyes)IBA 12/2016
1	ExotoxinsIBA 12/2016
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 12/2016
1	Lipid AIBA 01/2016
1	Cisplatin (Platino)FDA LinkGeneric 01/2011
1	CPX-351IBA 09/2010
1	Cytarabine (Cytosar-U)FDA LinkGeneric 09/2010
1	Daunorubicin (Cerubidine)FDA LinkGeneric 09/2010
1	Liposomes (Liposome)IBA 09/2010
1	gamma-Glutamyl Hydrolase (Carboxypeptidase G2)IBA 07/2008
1	Succinic Acid (Succinate)IBA 06/2008
1	NucleosidesIBA 01/2005
1	Thymidine KinaseIBA 01/2005
1	fialuridineIBA 01/2005
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2004
1	Fluorouracil (Carac)FDA LinkGeneric 07/2002

Therapy/Procedure

5	Therapeutics 12/2018 - 03/2002
1	Immunotherapy 12/2018
1	Immunomodulation 09/2003
1	Intravenous Administration 07/2002